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first-pass effect

/fɜrst pæs ɪˈfɛkt/ /fɜːst pɑːs ɪˈfɛkt/
noun
GeneralMedical
  1. 1 ilk geçiş etkisi uncountable

Definition (English)

The process where a drug is metabolized by the liver or gut wall before reaching the bloodstream, reducing its effect.

Example Sentences

  1. The first-pass effect destroyed most of the oral dose before it reached the bloodstream.
    İlk geçiş etkisi, kana ulaşmadan önce oral dozun çoğunu yok etti.
  2. You bypass the first-pass effect by giving the drug under the tongue or by injection.
    İlk geçiş etkisini, ilacı dil altından ya da enjeksiyonla vererek atlatırsınız.

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